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Stable and biocompatible genipin-inducing interlayer-crosslinked micelles for sustained drug release
Dai, Yu; Zhang, Xiaojin
2017
Source PublicationJOURNAL OF NANOPARTICLE RESEARCH
Volume19Issue:5
AbstractTo develop the sustained drug release system, here we describe genipin-inducing interlayer-crosslinked micelles crosslinked via Schiff bases between the amines of amphiphilic linear-hyperbranched polymer poly(ethylene glycol)-branched polyethylenimine-poly(epsilon-caprolactone) (PEG-PEI-PCL) and genipin. The generation of Schiff bases was confirmed by the color changes and UV-Vis absorption spectra of polymeric micelles after adding genipin. The particle size, morphology, stability, in vitro cytotoxicity, drug loading capacity, and in vitro drug release behavior of crosslinked micelles as well as non-crosslinked micelles were characterized. The results indicated that genipin-inducing interlayer-crosslinked micelles had better stability and biocompatibility than non-crosslinked micelles and glutaraldehyde-inducing interlayer-crosslinked micelles. In addition, genipin-inducing interlayer-crosslinked micelles were able to improve drug loading capacity, reduce the initial burst release, and achieve sustained drug release.
KeywordCrosslinking Drug controlled release Genipin Polymericmicelles Schiff base Nanomedicine
DOI10.1007/s11051-017-3866-y
Language英语
ISSN1388-0764
Indexed ByEI ; SCI
EI Accession Number20171803631839
WOS IDWOS:000413655100001
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
PublisherSPRINGER
Publication PlaceVAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
EISSN1572-896X
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.cug.edu.cn/handle/2XU834YA/276837
Collection教学院系_数学与物理学院
教学院系_材料与化学学院
Corresponding AuthorZhang, Xiaojin
AffiliationChina Univ Geosci, Fac Mat Sci & Chem, Wuhan 430074, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Dai, Yu,Zhang, Xiaojin. Stable and biocompatible genipin-inducing interlayer-crosslinked micelles for sustained drug release[J]. JOURNAL OF NANOPARTICLE RESEARCH,2017,19(5).
APA Dai, Yu,&Zhang, Xiaojin.(2017).Stable and biocompatible genipin-inducing interlayer-crosslinked micelles for sustained drug release.JOURNAL OF NANOPARTICLE RESEARCH,19(5).
MLA Dai, Yu,et al."Stable and biocompatible genipin-inducing interlayer-crosslinked micelles for sustained drug release".JOURNAL OF NANOPARTICLE RESEARCH 19.5(2017).
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