Stable and biocompatible genipin-inducing interlayer-crosslinked   micelles for sustained drug release

doi:10.1007/s11051-017-3866-y

	Stable and biocompatible genipin-inducing interlayer-crosslinked micelles for sustained drug release
	Dai, Yu; Zhang, Xiaojin
	2017
发表期刊	JOURNAL OF NANOPARTICLE RESEARCH
卷号	19 期号:5
摘要	To develop the sustained drug release system, here we describe genipin-inducing interlayer-crosslinked micelles crosslinked via Schiff bases between the amines of amphiphilic linear-hyperbranched polymer poly(ethylene glycol)-branched polyethylenimine-poly(epsilon-caprolactone) (PEG-PEI-PCL) and genipin. The generation of Schiff bases was confirmed by the color changes and UV-Vis absorption spectra of polymeric micelles after adding genipin. The particle size, morphology, stability, in vitro cytotoxicity, drug loading capacity, and in vitro drug release behavior of crosslinked micelles as well as non-crosslinked micelles were characterized. The results indicated that genipin-inducing interlayer-crosslinked micelles had better stability and biocompatibility than non-crosslinked micelles and glutaraldehyde-inducing interlayer-crosslinked micelles. In addition, genipin-inducing interlayer-crosslinked micelles were able to improve drug loading capacity, reduce the initial burst release, and achieve sustained drug release.
关键词	Crosslinking Drug controlled release Genipin Polymericmicelles Schiff base Nanomedicine
DOI	10.1007/s11051-017-3866-y
语种	英语
ISSN	1388-0764
收录类别	EI ; SCI
EI入藏号	20171803631839
WOS记录号	WOS:000413655100001
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
出版者	SPRINGER
出版地	VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
EISSN	1572-896X
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.cug.edu.cn/handle/2XU834YA/276837
专题	教学院系_数学与物理学院教学院系_材料与化学学院
通讯作者	Zhang, Xiaojin
作者单位	China Univ Geosci, Fac Mat Sci & Chem, Wuhan 430074, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Dai, Yu,Zhang, Xiaojin. Stable and biocompatible genipin-inducing interlayer-crosslinked micelles for sustained drug release[J]. JOURNAL OF NANOPARTICLE RESEARCH,2017,19(5).
APA	Dai, Yu,&Zhang, Xiaojin.(2017).Stable and biocompatible genipin-inducing interlayer-crosslinked micelles for sustained drug release.JOURNAL OF NANOPARTICLE RESEARCH,19(5).
MLA	Dai, Yu,et al."Stable and biocompatible genipin-inducing interlayer-crosslinked micelles for sustained drug release".JOURNAL OF NANOPARTICLE RESEARCH 19.5(2017).

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